Inactivation of sodium channels underlies reversible neuropathy during critical illness in rats
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چکیده
منابع مشابه
Inactivation of sodium channels underlies reversible neuropathy during critical illness in rats.
Neuropathy and myopathy can cause weakness during critical illness. To determine whether reduced excitability of peripheral nerves, rather than degeneration, is the mechanism underlying acute neuropathy in critically ill patients, we prospectively followed patients during the acute phase of critical illness and early recovery and assessed nerve conduction. During the period of early recovery fr...
متن کاملCritical Illness Neuropathy
It is usually associated with or accompanied with a coma producing septic encephalopathy. The neuropathy is usually not apparent and may be noted only when the brain dysfunction is resolving. Patients usually have a protracted hospital course complicated by multi-organ failure and the systemic inflammatory response syndrome. Elevated serum glucose levels and reduced albumin is risk factors for ...
متن کاملCritical illness neuropathy
Free full text available from www.ijccm.org A b st ra ct The neuromuscular syndrome of acute limb and respiratory weakness that commonly accompanies patients with multi-organ failure and sepsis constitutes critical illness polyneuropathy. It is a major cause of difficulty in weaning off the patient from the ventilator after respiratory and cardiac causes have been excluded. It is usually an axo...
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متن کاملThe effect of reversible inactivation of raphe nuclus on learning and memory in rats
The role of raphe nucleus (R.N) and serotonin in some behaviors such as sleep, cognition, mood, and memory has previously been reported. The median raphe (MR) nucleus is a major serotonin-containing cell group within the brainstem and is one of the main sources of projections to the septum and hippocampus. The hippocampus is widely believed to be essential for context-conditioning learning. Mor...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2009
ISSN: 0021-9738
DOI: 10.1172/jci36570